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Before centers were enrolled in the trial, we affirmed that standard recommended signals were acquired,24 and that data could be shared with the Core Lab (Mayo Clinic Center for Sleep Medicine), and that site scoring agreed with the Core Lab within set specifications. Sites converted PSGs to European Data Format (EDF) and electronically conveyed them to the Core Lab, along with copies of the corresponding technician notes. The PSGs were analyzed and scored by registered PSG technologists on Gamma software (Grass Technologies Corporation, West Warwick, RI) at the Core Lab, adhering to standardized scoring criteria.24 Between-technologist scoring agreement was tested in an ongoing fashion to affirm reproducibility. One board-certified sleep specialist (TIM) provided confirmatory clinical review and audit for each PSG. PSG reports were sent back to the sites after each review. Discrepancies in scoring, if any, were discussed between the Core Lab sleep specialists and the site specialist until agreement was achieved. The Core Lab confirmed final complex sleep apnea syndrome (CompSAS) diagnosis and that the CPAP pressure required to treat the participants was less than 15 cm H2O prior to visit 1 of the protocol. d2c66b5586